Nicotinamide mononucleotide (NMN)

Nicotinamide mononucleotide is a key NAD⁺ intermediate.

The main effects of NMN seen in various type of mice, during various studies are:   

NMN reverses vascular dysfunction and oxidative stress with aging

NMN-administered mice exhibit suppression of age-associated body weight gain

Long-term NMN administration significantly improves eye function, bone density, and myeloid-lymphoid composition in aged mice

NMN reduces vascular oxidative stress

NMN treatment normalizes aortic stiffness in old mice

Long-term NMN administration reverses age-associated gene expression changes in peripheral tissues and enhances mitochondrial respiratory capacity in skeletal muscle

NMN reduces large elastic artery stiffnes

NMN activates arterial SIRT1

NMN-administered mice show enhancement of energy metabolism and higher physical activity

NMN-administered mice show improved insulin sensitivity and plasma lipid profile

The study also demonstrates a reversal of age‐associated endothelial dysfunction by oral NMN supplementation

NMN treats the pathophysiology of diet- and age-induced diabetes in mice

NMN ameliorates defects in NAMPT-mediated NAD+ biosynthesis in HFD-induced diabetic mice 

NMN ameliorates hepatic insulin resistance and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm

NMN ameliorates metabolic complications in age-induced mice

NMN improves glucose and lipid homeostasis in age-induced mice