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Aspirin is a widely administered, cheap, anti-inflammatory and antioxidant compound

Aspirin has variety of positive effects on the immune system and cardiovascular health.

Notably, aspirin may affect oxidant production, cytokine responses, and block glycol oxidation reactions,

thus posing it as a triple threat against the symptoms of aging.

In animal studies, using aspirin to heal inflammation, resulted in extended lifespans, more physical

capability and increased stress resistance.

Aspirin and Low Dose Nitric Oxide-Donating Aspirin Increase Life Span in a Lynch Syndrome Mouse Model.

Aspirin extended longevity of C. Elegans, by up to 23 % in association with upregulated superoxide dismutase,

catalase, and glutathione S transferases (A3). This required DAF-16/FOXO and AMPK, supporting aspirin as a dietary restriction mimetic

Recent clinical trials report that regular aspirin use is associated with a lower risk of cancer-specific mortality

in individuals already diagnosed with colorectal (A1) or breast cancer (A2).

LS/HNPCC mouse data indicates that ASA and low dose NO-ASA requires continuous long-term treatment,

with a subsequent 18–21% increase in lifespan

Indeed, recently disclosed data suggest that long-term ASA treatment of LS/HNPCC patients appears to result

in a 50% decrease in tumor incidence

Dietary exposure to ASA and low dose NO-ASA increase survival of an LS/HNPCC mouse model

One study performed on crickets also found that aspirin was more effective at increasing maximum lifespan than metformin (see below) [A4].