Metformin

 

 METFORMIN             

 

Metformin is the most commonly prescribed medication for type 2 diabetes (T2DM) in the world.

It has primacy in the treatment of this disease because of its safety record and also because of evidence

for reduction in the risk of cardiovascular events.

Metformin has earned much credit in recent years as a potential anti-aging formula.

It has been shown to significantly increase lifespan and delay the onset of age-associated decline in several

experimental models.

 

Metformin mitigates the high risk of diabetics getting cardiovascular disease and brain issues.

The results of multiple studies suggest that metformin can protect against atherosclerosis

by promoting endothelial integrity and preventing the formation of plaques.

Metformin has also been observed to exhibit anti-thrombotic properties in insulin-resistant models,

and helps to protect against the development of coronary artery disease.

 

Metformin can also modify inflammatory processes known to play a role in cancer progression

There are several lines of evidence that suggest metformin can exert cancer preventative effects in a

cell-autonomous manner.

 

There is evidence that metformin improves the response of cancer cells to radiotherapy [M1].

Metformin has also been found to enhance the sensitivity of multiple cancer cell types 

to common chemotherapeutic agents including cisplatin, paclitaxel, carboplatin and doxorubicin

There is also evidence to suggest that metformin exerts a cardioprotective effect

against ischaemia reperfusion injury following myocardial infarction.

 

Administration of metformin during the first 15 min of reperfusion has been shown to reduce

myocardial infarct size in hearts isolated from both diabetic and non-diabetic rats

Taking metformin may be associated with reduced risk of cancer in patients with type 2 diabetes.

Of particular interest is the suggestion of a dose-response relationship.  [M2, M3]. 

Metformin Treatment Extends C. elegans Median Lifespan and Promotes Youthful Mobility Late into Adult Life

Metformin promotes mobility in old age, decreases the fat build up, and increases stress resilience

in response to oxygen deprivation [M4]

 

Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan

Recently, a study performed in the cricket Acheta domesticus [M5], shows that metformin leads

to an extension in mean and maximal lifespan of organisms of both sexes,

with increases of 43.7% and 23.2% in females and males respectively

 

Overall, metformin treatment of different type of mice, over a wide-range of doses led to increases

in lifespan ranging from 4% to 38%

 

Metformin is a prescription medication, so ask your doctor before you take it.